Volume 116, Issue 1, Pages 38-45 (January 1999) The κ agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome  Michel Delvaux, Dominique Louvel, Emmanuel Lagier, Bruno Scherrer, Jean-Louis Abitbol, Jacques Frexinos  Gastroenterology  Volume 116, Issue 1, Pages 38-45 (January 1999) DOI: 10.1016/S0016-5085(99)70226-X Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Study design, including the phase of selection of patients and the experimental procedures in protocols 1 (distention) and 2 (tone recording). Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Cumulative number of patients positively responding for the (A) first sensation threshold and (B) pain threshold on placebo (- - - -) and 100 mg fedotozine (—) intravenously. Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Cumulative number of patients positively responding for the (A) first sensation threshold and (B) pain threshold on placebo (- - - -) and 100 mg fedotozine (—) intravenously. Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Volume measured in the barostat bag at the (A) first sensation and (B) pain thresholds. Baseline distention was performed in the morning without any treatment. A second distention session was performed in the afternoon during the random infusion of placebo or 100 mg fedotozine. Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Volume measured in the barostat bag at the (A) first sensation and (B) pain thresholds. Baseline distention was performed in the morning without any treatment. A second distention session was performed in the afternoon during the random infusion of placebo or 100 mg fedotozine. Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Pressure-volume curve on placebo (▩) and 100 mg fedotozine (■) intravenously. Values are expressed as means ± SD of volumes measured in each patient. Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 5 Volume of the barostat bag placed in the left colon under a constant operating pressure, defined as the pressure allowing the recording of respiratory movements plus 2 mm Hg. In the fasted state, the bag volume is slightly increased on fedotozine compared with placebo (P = 0.035), indicating that fedotozine might induce a moderate relaxation of the colon. Variations of the barostat bag volume reflect changes in colonic tone. These changes are characterized by a dramatic decrease of the bag volume in the postprandial period on both placebo (■) and fedotozine (▩). Gastroenterology 1999 116, 38-45DOI: (10.1016/S0016-5085(99)70226-X) Copyright © 1999 American Gastroenterological Association Terms and Conditions