Squamous-cell transformation in a patient with lung adenocarcinoma receiving erlotinib: Co-occurrence with T790M mutation Diogo D.G. Bugano, Neda Kalhor,

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Squamous-cell transformation in a patient with lung adenocarcinoma receiving erlotinib: Co-occurrence with T790M mutation Diogo D.G. Bugano, Neda Kalhor, Jianjun Zhang, Michele Neskey, William N. William Cancer Treatment and Research Communications Volume 4, Pages 34-36 (January 2015) DOI: 10.1016/j.ctrc.2015.03.007 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Pathology specimens. (A) Original pleural effusion from 2010 shows adenocarcinoma. (B) Cells in the original specimen are positive for TTF-1. (C) Re-biopsy after 2 lines of chemotherapy and 22 months of erlotinib is suggestive of squamous cell carcinoma which is TTF-1 negative (D) and p40 positive (E). Cancer Treatment and Research Communications 2015 4, 34-36DOI: (10.1016/j.ctrc.2015.03.007) Copyright © 2015 Elsevier Ltd Terms and Conditions