Volume 9, Issue 2, Pages (August 2011)

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Presentation transcript:

Volume 9, Issue 2, Pages 95-96 (August 2011) EPO and Super-EPO: Erythropoietins Direct Neoangiogenesis by Cardiac Progenitor Cells Michael D. Schneider Cell Stem Cell Volume 9, Issue 2, Pages 95-96 (August 2011) DOI: 10.1016/j.stem.2011.07.008 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 The STAT3-EPO-CCL2 Pathway for Cardiac Blood Vessel Formation and Its Dysregulation in Heart Failure Cardiomyocytes' expression of STAT3 is essential for local EPO production, which directs the differentiation of Sca-1+ CPCs into vascular endothelium. Methoxy polyethylene glycol-epoetin beta, a long-lasting EPO derivative, can bypass the requirement for endogenous EPO production, activate blood vessel formation by Sca-1+ CPCs, improve cardiac pump function in the conditional knockout of STAT3, and overcome doxorubicin-induced cardiotoxicity. Cell Stem Cell 2011 9, 95-96DOI: (10.1016/j.stem.2011.07.008) Copyright © 2011 Elsevier Inc. Terms and Conditions