Evaluation of Th1/Th2 cytokines as a rapid diagnostic tool for severe infection in paediatric haematology/oncology patients by the use of cytometric bead.

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Presentation transcript:

Evaluation of Th1/Th2 cytokines as a rapid diagnostic tool for severe infection in paediatric haematology/oncology patients by the use of cytometric bead array technology Y. Tang, C. Liao, X. Xu, H. Song, S. Shi, S. Yang, F. Zhao, W. Xu, X. Chen, J. Mao, L. Zhang, B. Pan Clinical Microbiology and Infection Volume 17, Issue 11, Pages 1666-1673 (November 2011) DOI: 10.1111/j.1469-0691.2011.03490.x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Comparison of cytokine levels among patients with microbiologically documented infection (MDI), healthy controls and newly admitted patients with acute leukaemia, aplastic anaemia, immune thrombocytopenic purpura, neuroblastoma, and lymphoma without fever (new admission group). (a) Interleukin (IL)-2; (b) IL-4; (c) IL-6; (d) IL-10; (e) tumour necrosis factor (TNF)-α; (f) interferon (IFN)-γ. Clinical Microbiology and Infection 2011 17, 1666-1673DOI: (10.1111/j.1469-0691.2011.03490.x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Comparison of the cytokine levels between febrile patients with or without septic shock. (a) Interleukin (IL-4); (b) IL6; (c) IL-10; (d) tumour necrosis factor (TNF)-α. Clinical Microbiology and Infection 2011 17, 1666-1673DOI: (10.1111/j.1469-0691.2011.03490.x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Comparison of Th1/Th2 cytokine levels at onset of infection and after the infection had been controlled. The former sample was taken at the time of fever within 24 h, and the latter was taken when the body temperature had returned to normal for at least 24 h. All of the elevated cytokine levels significantly decreased after infection had been controlled, except for interleukin (IL)-2 (p <0.001). (a) IL-2; (b) IL-4; (c) IL-6; (d) IL-10; (e) tumour necrosis factor (TNF)-α; (f) interferon (IFN)-γ. Clinical Microbiology and Infection 2011 17, 1666-1673DOI: (10.1111/j.1469-0691.2011.03490.x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions