Association of erosive hand osteoarthritis with a single nucleotide polymorphism on the gene encoding interleukin-1 beta A.G Stern, M.D., M.R.C de Carvalho,

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Association of erosive hand osteoarthritis with a single nucleotide polymorphism on the gene encoding interleukin-1 beta A.G Stern, M.D., M.R.C de Carvalho, M.S., G.A Buck, Ph.D., R.A Adler, M.D., T.P.S Rao, M.D., D Disler, M.D., G Moxley, M.D. Osteoarthritis and Cartilage Volume 11, Issue 6, Pages 394-402 (June 2003) DOI: 10.1016/S1063-4584(03)00054-2

Fig. 1 Radiographic features of erosive OA. Notable for central, cartilage-based, ‘gull-wing’ erosions (white arrow, typical example). Multiple IP joints with asymmetric joint-space narrowing, along with subchondral sclerosis, and osteophytes. There is a relative sparing of the MCP joints. Osteoarthritis and Cartilage 2003 11, 394-402DOI: (10.1016/S1063-4584(03)00054-2)

Fig. 2 IL-1 region linkage disequilibrium. Schematic representation of selected IL-1 region loci on human chromosome 2q, drawn from the draft sequence, June 2002 freeze of the Human Genome Project (http://www.genome.ucsc.edu). Distances between loci are not to scale; that between IL1A and IL1B is approximately 52kb, between IL1B and IL1RN is nearly 300kb. Individual SNP and VNTR markers are represented as vertical lines, exons are boxes. Each arrow represents the direction of transcription for the individual locus. Numbers and lines below map represent disequilibrium statistics: the D′ value (pairwise standardized disequilibrium coefficient) is shown at the end of each line; statistically significant linkage disequilibrium (p<0.05) between IL1B 5810 SNP and other nearby markers and IL1B 5810 SNP is depicted with solid lines and p>0.05 is represented by dashed lines. Osteoarthritis and Cartilage 2003 11, 394-402DOI: (10.1016/S1063-4584(03)00054-2)