Volume 22, Issue 5, Pages (November 2017)

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Volume 22, Issue 5, Pages 575-576 (November 2017) Mind Your Cs and Gs Oliver I. Fregoso Cell Host & Microbe Volume 22, Issue 5, Pages 575-576 (November 2017) DOI: 10.1016/j.chom.2017.10.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 ZAP Shapes Viral RNA Sequence Evolution (A) In the absence of ZAP, RNA viruses have more potential evolutionary space to sample diverse dinucleotides. (B) However, ZAP antiviral activity, which uses CG dinucleotides as a means to differentiate self from non-self, constrains the evolutionary space. This ultimately selects for RNA viruses with low CG dinucleotide composition. Cell Host & Microbe 2017 22, 575-576DOI: (10.1016/j.chom.2017.10.012) Copyright © 2017 Elsevier Inc. Terms and Conditions