Fig. 1. Schematic representation of the MANO method.

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Fig. 1. TP is highly expressed in myeloma.

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Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.

Transfer of miR-223 during neutrophil-epithelial cell interactions

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

Fig. 2. Pharmacologic inhibition of ALK impairs STING activation.

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

Fig. 4. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive and HBeAg-negative chimpanzees. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive.

Fig. 2 miRNA181a targets NFAT5 in human CD4+ T cells.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 4. Functional annotation of VUS in EGFR.

Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

Fig. 6. Pathway analysis of CMLD

Fig. 3. BET inhibition reduces homologous recombination.

Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.

Fig. 3. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with ARC-520. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Fig. 4 Topical application of SAAP-148 ointment eradicates acute and established infections of MRSA and A. baumannii from the skin. Topical application.

Fig. 2. GPC3 expression in normal and tumor tissues.

Fig. 4. The effects of AVP or d(Leu4Lys8)VP, a specific AVPR1B agonist, on anemic rodents. The effects of AVP or d(Leu4Lys8)VP, a specific AVPR1B agonist,

Fig. 6. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific CTL immunity in vitro. PVSRIPO oncolysate–pulsed DCs generate tumor antigen–specific.

Increased ADMA in pregnancy is associated with SGA birth outcomes

Fig. 5 A competent Fc is required for the antitumor immune response.

Fig. 1 Chemical inactivation of BPL kills Mtb and prevents growth in mouse macrophages. Chemical inactivation of BPL kills Mtb and prevents growth in mouse.

Fig. 5. Stimulation of EPO expression and secretion under hypoxic culture conditions. Stimulation of EPO expression and secretion under hypoxic culture.

Identification of bioactive compounds modulating STING activation

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 1. scRNA-seq applications in cancer medicine.

Fig. 1. Generation of the ΔEx50 mouse model.

Fig. 4. MATE1 transcription in RCC.

Fig. 2 STED microscopy of isolated cardiomyocytes from mice treated with MP-rhodamine–loaded CaPs. STED microscopy of isolated cardiomyocytes from mice.

Fig. 6 Malaria and l-arginine induce changes in the expression of inflammatory and angiogenic mediators in placental tissue by reverse transcription PCR.

Fig. 5. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic composition. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic.

Fig. 5. MMP-7 expression in human liver, EHBD, and gallbladder.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Representative CT and PET/CT images of three patients with NSCLCs

Fig. 5 EGFR mutation status of patients with NSCLC, detected by histological examination and ARMS PCR. EGFR mutation status of patients with NSCLC, detected.

Antiproliferative effects of JQ-EZ-05 on VHL−/− ccRCC are on-target

Fig. 3. Recovery of AVP-deficient rats from anemia induced by sublethal irradiation. Recovery of AVP-deficient rats from anemia induced by sublethal irradiation.

Fig. 5 Local gel scaffold for T cell memory response.

Fig. 2 Fas controls IL-1RA–sEV secretion in murine MSCs.

Fig. 1 HIV transcription profiles in freshly isolated CD4+ T cells and PBMCs from HIV-infected patients on ART suggest blocks to HIV transcriptional elongation,

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

Fig. 2 Analysis of CLL lymph nodes.

Fig. 3. TKI sensitivity assessed by the MANO method.

Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.

Fig. 6. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections.

CD facilitates RCT in vivo and promotes urinary cholesterol excretion

Bexarotene is neuroprotective in mouse and human HD neurons in vitro

Fig. 6. CXM correlates with age and growth velocity.

Fig. 5. Prophylactic and therapeutic efficacy of C12G6 in ferrets.

Fig. 3 CSF1 is expressed in human melanoma.

Stroke induces inflammatory activation of the aortic endothelium

Fig. 7 Analysis of the bacterial nidus within tissue abscesses by MALDI IMS demonstrates a paucity of calprotectin signal. Analysis of the bacterial nidus.

IIV induces CD21hiCD27+ and CD21loCD27+ influenza-specific B cells

Fig. 5 BRD0705 induces differentiation in AML cell lines and primary patient samples through GSK3α-selective inhibition. BRD0705 induces differentiation.

Fig. 3 Activation of freshly isolated CD4+ T cells from HIV-infected patients on ART selectively reverses baseline blocks to splicing, elongation, and.

JAK2 knockdown abrogates tumorsphere expansion after chemotherapy

Fig. 5 Early and modest immune response at day 3 after exposure in Delayed animals. Early and modest immune response at day 3 after exposure in Delayed.

Fig. 5 Wireless, full-body pressure mapping on a human subject in a hospital bed. Wireless, full-body pressure mapping on a human subject in a hospital.

Fig. 4 ALRN-6924 inhibits cellular proliferation and clonogenic capacity, and induces cell cycle arrest and apoptosis in AML cell lines. ALRN-6924 inhibits.

Fig. 2. BET inhibition enhances PARPi-induced DNA damage.

Fig. 4. Induced Zbtb7a in lungs is localized to AMs.

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

Cloning and expression of rat nesprin-1.

Fig. 1 Intra-amniotic delivery of CRISPR-Cas9 results in pulmonary gene editing. Intra-amniotic delivery of CRISPR-Cas9 results in pulmonary gene editing.

PD and efficacy of AZD4785 in a KRAS wild-type lung cancer PDX model

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Fig. 1. Schematic representation of the MANO method. Schematic representation of the MANO method. Mouse 3T3 or Ba/F3 cells were infected with recombinant retrovirus expressing oncoproteins with corresponding 6-bp bar codes. Equal numbers of the stably transduced cells were mixed and cultured with different types of medium and/or treated with TKIs or vehicle. gDNA was harvested from the mixture of the remaining viable cells at the appropriate periods for each assay. The bar code sequences were PCR-amplified and subjected to deep sequencing on MiSeq sequencers to quantitate their relative abundance (a direct reflection of the cell number). To evaluate the transforming potential of each oncoprotein, the read number for each bar code was normalized to that of day 0. To evaluate the inhibition profile of test compounds across transduced clones in the mixture, the read number for each bar code was normalized to that of the vehicle-treated control. WT, wild-type. Shinji Kohsaka et al., Sci Transl Med 2017;9:eaan6566 Published by AAAS