The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm Lambert Speelman, MSc, Geert Willem H. Schurink, PhD, MD, E. Marielle.

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Presentation transcript:

The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm Lambert Speelman, MSc, Geert Willem H. Schurink, PhD, MD, E. Marielle H. Bosboom, PhD, Jaap Buth, PhD, MD, Marcel Breeuwer, PhD, Frans N. van de Vosse, PhD, Michael H. Jacobs, PhD, MD Journal of Vascular Surgery Volume 51, Issue 1, Pages 19-26 (January 2010) DOI: 10.1016/j.jvs.2009.08.075 Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 1 The idealized axisymmetric abdominal aortic aneurysm (AAA) models without and with thrombus, with a minimum layer of 2 mm thrombus and a maximum thrombus thickness ranging from 2 to 12 mm (18%-57% relative thrombus volume). Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 2 The surfaces of the lumen (magenta), the thrombus (yellow) and the AAA wall (purple) displayed in the CT-scan (left). The resulting finite element mesh (right). Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 3 The change in wall stress due to the presence of thrombus as a function of the thrombus shear modulus for a thrombus thickness 2-12 mm (left) and as a function of the relative thrombus volume for thrombus shear moduli of 4, 10, 40, 100, and 180 kPa (right). Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 4 Box-and-whisker plot for the abdominal aortic aneurysm (AAA) growth rates (mm/year) of groups A and B (Kruskal-Wallis test; P < .01). Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 5 Wall stress distributions for an abdominal aortic aneurysm (AAA) with a 23% relative thrombus volume. Anterior (top row) and posterior (bottom row) views of the cut-through mesh (lumen boundary in red, thrombus in yellow, wall in blue) and the wall stress without thrombus and with thrombus. Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 6 Wall stress distributions for an abdominal aortic aneurysm (AAA) with a 55% relative thrombus volume. Anterior (top row) and posterior (bottom row) views of the cut-through mesh (lumen boundary in red, thrombus in yellow, wall in blue) and the wall stress without thrombus and with thrombus. The black arrows indicate locations of changed wall stress due to the presence of thrombus. Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 7 The change in wall stress due to the thrombus and the relative thrombus volume for all patient-specific abdominal aortic aneurysm (AAA) models and for the idealized axisymmetric AAA model (thrombus shear modulus of 40 kPa). Journal of Vascular Surgery 2010 51, 19-26DOI: (10.1016/j.jvs.2009.08.075) Copyright © 2010 Society for Vascular Surgery Terms and Conditions