Parkinson’s Disease: A Traffic Jam? Michael J. Clague, Leila Rochin  Current Biology  Volume 26, Issue 8, Pages R332-R334 (April 2016) DOI: 10.1016/j.cub.2016.03.001 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Schematic view of cellular compartmentalisation and the association of specific Rabs and Parkinson’s disease-associated proteins (boxes) with individual trafficking steps. Confirmed phosphosites that are sensitive to LRRK2 (in green) and PINK1 (in pink) are indicated by solid circles, potential sites based on homology are indicated by dotted circles. TfR, transferrin receptor; EGFR, epidermal growth factor receptor; CCP, clathrin-coated pits; TGN, trans-Golgi network; MDV, mitochondrial-derived vesicles; ER, endoplasmic reticulum. Current Biology 2016 26, R332-R334DOI: (10.1016/j.cub.2016.03.001) Copyright © 2016 Elsevier Ltd Terms and Conditions