Covering the Cover Gastroenterology Anson W. Lowe, Richard H. Moseley  Gastroenterology  Volume 146, Issue 4, Pages 875-877 (April 2014) DOI: 10.1053/j.gastro.2014.02.028 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Kaplan–Meier survival curves across all cancer stages. Gastroenterology 2014 146, 875-877DOI: (10.1053/j.gastro.2014.02.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Summary of TTC7 mutations. Schematic representation of the role of TTC7A in the trafficking of PI4KIIIα to the plasma membrane from the trans-Golgi network. The left panel represents WT TTC7A in enterocytes wherein TTC7A binds to and facilitates the transport of PI4KIIIα from the trans-Golgi to the plasma membrane. At the membrane, PI4KIIIα can catalyze the production of PtdIns-4P(PI-4P). PI-4P levels at the plasma membrane have been implicated in cell survival and the maintenance of cell polarity. In the right panel, the various TTC7A mutations identified in the patients are depicted. E71K, Q526X, and A832T TTC7A all demonstrated reduced binding to PI4KIIIα, which could reduce the interaction between TTC7A and PI4KIIIα, hindering transport to the plasma membrane (PM). Consequently, this will lead to reduced plasma membrane levels of PI-4P, a dysregulation that would affect downstream signaling pathways. Gastroenterology 2014 146, 875-877DOI: (10.1053/j.gastro.2014.02.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Survival from acute pancreatitis with 2 different dosing regimens of l-arginine. CH, conditional null mutation of HMGB1; F, floxed control. Gastroenterology 2014 146, 875-877DOI: (10.1053/j.gastro.2014.02.028) Copyright © 2014 AGA Institute Terms and Conditions