Pharmacokinetics and pharmacodynamics of anti-thymocyte globulin in recipients of partially HLA-matched blood hematopoietic progenitor cell transplantation

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Presentation transcript:

Pharmacokinetics and pharmacodynamics of anti-thymocyte globulin in recipients of partially HLA-matched blood hematopoietic progenitor cell transplantation Edmund K Waller, Amelia A Langston, Sagar Lonial, Judy Cherry, Jyoti Somani, Andrew J Allen, Hilary Rosenthal, Istvan Redei Biology of Blood and Marrow Transplantation Volume 9, Issue 7, Pages 460-471 (July 2003) DOI: 10.1016/S1083-8791(03)00127-7

Figure 1 Higher numbers of peripheral blood T cells in PMRD transplant recipients conditioned with e-ATG versus r-ATG. Mean numbers (with SD error bars) of CD4+ and CD8+ T cells in the blood of PMRD transplant recipients conditioned with 60 mg//kg e-ATG (n=3; dashed lines) were compared with mean numbers of circulating T cells in PMRD transplant recipients conditioned with 6 mg/kg (n=21) r-ATG (solid lines). Biology of Blood and Marrow Transplantation 2003 9, 460-471DOI: (10.1016/S1083-8791(03)00127-7)

Figure 2 Delayed immune reconstitution among recipients of r-ATG and PMRD transplantation. Mean levels of blood CD56+ NK cells (squares), CD3+ T cells (diamonds), or CD19+ B-cells (circles) were determined by flow cytometry for recipients of PMRD transplants treated with 6 mg/kg r-ATG (n=21). SD of the mean values are shown as error bars. Biology of Blood and Marrow Transplantation 2003 9, 460-471DOI: (10.1016/S1083-8791(03)00127-7)

Figure 3 Effect of ATG timing on GVHD in CD34+ selected blood HPC transplant recipients. Plasma levels of total (upper lines) and active (lower lines) of r-ATG were measured in a recipient of a CD34+-selected blood HPC graft from a HLA-matched sibling conditioned with a total of 11.5 mg/kg ATG (black bar) before 12 Gy TBI and 120 mg/kg cyclophosphamide (grey bar; panel A), or a recipient of a CD34-selected, CD2-depleted blood HPC graft from a partially matched (haplo-identical) sibling conditioned with 12 Gy TBI, 10 mg/kg thiotepa and 200 mg/kg fludarabine (grey bar) followed by 10 mg/kg ATG (black bar; panel B). Biology of Blood and Marrow Transplantation 2003 9, 460-471DOI: (10.1016/S1083-8791(03)00127-7)

Figure 4 Clearance of total and active r-ATG. The fraction of the day 0 peak level of total and active r-ATG were calculated for each recipient of PMRD transplant for each time point pre- and posttransplant (n=19). Biology of Blood and Marrow Transplantation 2003 9, 460-471DOI: (10.1016/S1083-8791(03)00127-7)

Figure 5 Relationship between donor/recipient age and T-cell recovery posttransplantation. Biology of Blood and Marrow Transplantation 2003 9, 460-471DOI: (10.1016/S1083-8791(03)00127-7)