Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber Friedrich Horak, MD, Petra.

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Presentation transcript:

Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber Friedrich Horak, MD, Petra Zieglmayer, MD, René Zieglmayer, Dipl Ing, Patrick Lemell, PhD, Philippe Devillier, MD, PhD, Armelle Montagut, Michel Mélac, MD, Sylvie Galvain, PharmD, Stéphanie Jean-Alphonse, PhD, Laurence Van Overtvelt, PhD, Philippe Moingeon, PhD, Martine Le Gall Journal of Allergy and Clinical Immunology Volume 124, Issue 3, Pages 471-477.e1 (September 2009) DOI: 10.1016/j.jaci.2009.06.006 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study design. Journal of Allergy and Clinical Immunology 2009 124, 471-477.e1DOI: (10.1016/j.jaci.2009.06.006) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Patient distribution. AEs leading to patient withdrawal: 300-IR group, oral inflammation after dental surgery; placebo group, headache∗ (included in the PP population) and pneumonia. Journal of Allergy and Clinical Immunology 2009 124, 471-477.e1DOI: (10.1016/j.jaci.2009.06.006) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Mean RTSS at baseline and mean ARTSS at each challenge. Adjusted means for baseline covariate and SE: A, baseline challenge, mean RTSS ITT population; B, All allergen challenges mean ARTSS-ITT population. Journal of Allergy and Clinical Immunology 2009 124, 471-477.e1DOI: (10.1016/j.jaci.2009.06.006) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Assessment of antibody responses: 5-grass-pollen extract–specific IgEs (upper panel) and IgGs (lower panel) before (visit 3) and after (visit 7) 4 months of treatment. Journal of Allergy and Clinical Immunology 2009 124, 471-477.e1DOI: (10.1016/j.jaci.2009.06.006) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions