Malignant B-Cell Lymphoma Arising in a Large, Left Atrial Myxoma

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Malignant B-Cell Lymphoma Arising in a Large, Left Atrial Myxoma Kamellia R. Dimitrova, MD, Darryl M. Hoffman, MD, Charles M. Geller, MD, Prashan Thiagarjah, MD, Julie Master, MD, Marvin Berger, MD, Robert F. Tranbaugh, MD The Annals of Thoracic Surgery Volume 89, Issue 2, Pages 626-629 (February 2010) DOI: 10.1016/j.athoracsur.2009.06.096 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Transthoracic echocardiography four chamber view of the tumor. (A) Heart in systole. (B) Heart in diastole. (LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle.) The Annals of Thoracic Surgery 2010 89, 626-629DOI: (10.1016/j.athoracsur.2009.06.096) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Histologic sections showed an atrial myxoma cells (on the right) and primary cardiac lymphoma (on the left). (Hematoxylin and eosin; ×150.) (B) Histology of the tumor showing lymphoid cells with occasional mitoses. (Hematoxylin and eosin; × 400). (C) Histology of the tumor showing myxoma cells. (Hematoxylin and eosin; ×300). The Annals of Thoracic Surgery 2010 89, 626-629DOI: (10.1016/j.athoracsur.2009.06.096) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Immunohistochemical studies of the malignant cells stained positively with antibodies directed against CD20, Ki-67, and CD10, and the in-situ hybridization for lambda and kappa light chains confirmed the diagnosis of malignant B-cell lymphoma. (B) Calretinin expression by the myxoma cells. The Annals of Thoracic Surgery 2010 89, 626-629DOI: (10.1016/j.athoracsur.2009.06.096) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions