Profile of eicosanoid generation in aspirin-intolerant asthma and anaphylaxis assessed by new biomarkers Noritaka Higashi, MD, PhD, Haruhisa Mita, PhD,

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Profile of eicosanoid generation in aspirin-intolerant asthma and anaphylaxis assessed by new biomarkers Noritaka Higashi, MD, PhD, Haruhisa Mita, PhD, Emiko Ono, MD, PhD, Yuma Fukutomi, MD, Hiromichi Yamaguchi, MD, Keiichi Kajiwara, BSc, Hidenori Tanimoto, MD, Kiyoshi Sekiya, MD, Kazuo Akiyama, MD, Masami Taniguchi, MD, PhD Journal of Allergy and Clinical Immunology Volume 125, Issue 5, Pages 1084-1091.e6 (May 2010) DOI: 10.1016/j.jaci.2009.12.977 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Time-course of urinary eicosanoid concentrations in the anaphylaxis group. The log-transformed urinary eicosanoid concentrations are expressed as medians and interquartile ranges. Anaphylaxis groups are denoted by closed triangles. ∗P < .05 compared with baseline values. †P < .05 for the comparison between the urinary PGF2α and ent-PGF2α concentrations. Urine samples were collected at baseline and after the reactions. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Significant correlations among urinary concentrations of LTE4, 2,3-dinor-9α,11β-PGF2 and 9α,11β-PGF2 in the AIA and anaphylaxis groups. Urinary eicosanoids values are expressed by using the log scale. AIA and anaphylaxis groups are denoted by the closed circles and triangles, respectively. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Time-course of urinary concentrations of LTE4, 2,3-dinor-9α,11β-PGF2 and 9α,11β-PGF2 in the AIA and ATA groups. AIA and ATA are denoted by closed circles and squares, respectively. The results are expressed as in Fig 1. ∗P < .05 compared with each respective baseline values. ‡P < .01 in comparison of baseline values between the AIA group and the ATA group. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Time-course of urinary concentrations of PGE2, PGF2α and ent-PGF2α in the AIA and ATA groups. Abbreviations and the results are expressed as in Fig 3. †P < .05 in the comparison of the baseline values between the AIA group and the ATA group. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

PGD2 metabolites in urine. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Mass spectrum of 2,3-dinor-9α,11β-PGF2 pentafluorobenzyl trimethylsilyl (TMS) ether derivative. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Specificity of determination 2,3-dinor-9α,11β-PGF2 in urine. Journal of Allergy and Clinical Immunology 2010 125, 1084-1091.e6DOI: (10.1016/j.jaci.2009.12.977) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions