Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled.

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Presentation transcript:

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial Craig Mowat, MD, Ian Arnott, MD, Aiden Cahill, MB, Malcolm Smith, MBChB, Tariq Ahmad, DPhil, Sreedhar Subramanian, MD, Simon Travis, FRCP, John Morris, FRCP, John Hamlin, PhD, Anjan Dhar, DM, Chuka Nwokolo, MD, Cathryn Edwards, DPhil, Tom Creed, MD, Stuart Bloom, FRCP, Mohamed Yousif, FRCP, Linzi Thomas, MD, Simon Campbell, MD, Stephen J Lewis, FRCP, Shaji Sebastian, FRCP, Sandip Sen, MRCP, Simon Lal, PhD, Prof Chris Hawkey, FMedSci, Charles Murray, PhD, Fraser Cummings, DPhil, Jason Goh, MD, James O Lindsay, PhD, Naila Arebi, PhD, Lindsay Potts, MBChB, Aileen J McKinley, MBChB, John M Thomson, PhD, John A Todd, MD, Mhairi Collie, MD, Prof Malcolm G Dunlop, MD, Prof Ashley Mowat, MBChB, Daniel R Gaya, FRCP, Jack Winter, MD, Graham D Naismith, MBChB, Holly Ennis, PhD, Catriona Keerie, MSc, Steff Lewis, PhD, Prof Robin J Prescott, PhD, Nicholas A Kennedy, MBBS, Prof Jack Satsangi, DPhil The Lancet Gastroenterology & Hepatology Volume 1, Issue 4, Pages 273-282 (December 2016) DOI: 10.1016/S2468-1253(16)30078-4 Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 TOPPIC trial profile The Lancet Gastroenterology & Hepatology 2016 1, 273-282DOI: (10.1016/S2468-1253(16)30078-4) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Kaplan-Meier plot for the primary outcome of time to clinical recurrence of postoperative Crohn's disease The Lancet Gastroenterology & Hepatology 2016 1, 273-282DOI: (10.1016/S2468-1253(16)30078-4) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 Unadjusted subgroup analyses of the primary outcome of clinical recurrence of postoperative Crohn's disease The Lancet Gastroenterology & Hepatology 2016 1, 273-282DOI: (10.1016/S2468-1253(16)30078-4) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 4 Unadjusted subgroup analyses of the secondary outcome of clinical recurrence The Lancet Gastroenterology & Hepatology 2016 1, 273-282DOI: (10.1016/S2468-1253(16)30078-4) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions