Volume 77, Issue 10, Pages (May 2010)

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Volume 77, Issue 10, Pages 913-920 (May 2010) Hemolysis is associated with acute kidney injury during major aortic surgery Iris C. Vermeulen Windsant, Maarten G. Snoeijs, Sebastiaan J. Hanssen, Sibel Altintas, John H. Heijmans, Thomas A. Koeppel, Geert Willem H. Schurink, Wim A. Buurman, Michael J. Jacobs Kidney International Volume 77, Issue 10, Pages 913-920 (May 2010) DOI: 10.1038/ki.2010.24 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Hemolysis and renal damage during open thoracic or thoracoabdominal aortic repair. (a) Hemolysis and (b) renal proximal tubular epithelial damage during open thoracic or thoracoabdominal aortic repair in patients with (N=19) and without (N=16) acute kidney injury. Urinary NAG concentrations were corrected for urine creatinine values. *P<0.05, **P<0.01, ***P<0.001 compared with preoperative levels. #P<0.05 between AKI and non-AKI patients. AKI, acute kidney injury; CPB, cardiopulmonary bypass; fHb, free hemoglobin, NAG, N-acetyl-β-D-glucosaminidase; R, reperfusion. Kidney International 2010 77, 913-920DOI: (10.1038/ki.2010.24) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Correlation of total plasma fHb release and urinary NAG excretion during the entire study period. Data were log transformed before entering into the Pearson's correlation test. AUC, area under the curve; fHb, free hemoglobin; NAG; N-acetyl-β-D-glucosaminidase. Kidney International 2010 77, 913-920DOI: (10.1038/ki.2010.24) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 3 Receiver-operating characteristics (ROC) curve presenting sensitivity and 1-specificity for peak plasma fHb levels at 2 h reperfusion (black line) and peak urine NAG levels at 15 min reperfusion (dotted line). AUC, area under the receiver-operating characteristics curve; fHb, free hemoglobin; NAG, N-acetyl-β-D-glucosaminidase. Kidney International 2010 77, 913-920DOI: (10.1038/ki.2010.24) Copyright © 2010 International Society of Nephrology Terms and Conditions