Window of Opportunity in RA

Slides:

Advertisements

Similar presentations

Mindanao, Malvin Ace D Reflection on rheumatoid arthritis.

Advertisements

Total Knee Arthroplasty in Juvenile Rheumatoid Arthritis by David H. Palmer, Kevin J. Mulhall, Corey A. Thompson, Erik P. Severson, Edward R.G. Santos,

Early Clinical and Radiographic Characteristics in Fibrodysplasia Ossificans Progressiva by Kenichi Mishima, Hiroshi Kitoh, Takenobu Katagiri, Hiroshi.

Radiographic and Histologic Assessment of Calcium Sulfate in Experimental Animal Models and Clinical Use as a Resorbable Bone-Graft Substitute, a Bone-Graft.

Total Knee Arthroplasty in a Patient with Erdheim-Chester Disease with Massive Joint Destruction by Andre F. Steinert, Stefan Reppenhagen, Bernd Baumann,

What is the definition of remission in RA? American Rheumatism Association (ARA)¹ Five or more of the following criteria must be fulfilled for at least.

Frank B. Hu et al N Engl J Med 2004; 351: Body-Mass Index and Relative Risk of Death from All Causes during 24 Years of Follow-up.

Primary Total Hip Arthroplasty After Infection

Achieving Stability and Lower-Limb Length in Total Hip Arthroplasty by Keith R. Berend, Scott M. Sporer, Rafael J. Sierra, Andrew H. Glassman, and Michael.

Lyme Arthritis in Children Presenting with Joint Effusions by Matthew D. Milewski, Aristides I. Cruz, Christopher P. Miller, Ashley T. Peterson, and Brian.

Consultant Rheumatologist

Correction of Sagittal Plane Spinal Deformities with Unit Rod Instrumentation in Children with Cerebral Palsy by Glenn E. Lipton, Eric J. Letonoff, Kirk.

Infectious arthritis Bacterial Viral Other Postinfectious (reactive) arthritis Rheumatic fever Reactive arthritis Enteric infection Other seronegative.

Prospective, Randomized, Multicenter Food and Drug Administration Investigational Device Exemption Study of the ProDisc-L Total Disc Replacement Compared.

Total Knee Arthroplasty in Patients with Ankylosing Spondylitis by Javad Parvizi, Gavan P. Duffy, and Robert T. Trousdale J Bone Joint Surg Am Volume 83(9):

Single-Leg-Stance Radiographs in the Diagnosis of Pelvic Instability by Jodi Siegel, David C. Templeman, and Paul Tornetta J Bone Joint Surg Am Volume.

High Impact Rheumatology For Primary Care Physicians.

Repair of a Pseudarthrosis of the Lumbar Spine. A Functional Outcome Study*† by MAJOR CLYDE T. CARPENTER, MAJOR JOHN W. DIETZ, KENNETH Y. K. LEUNG, DAVID.

Arthroscopic Management of Septic Arthritis of the Shoulder Joint by In-Ho Jeon, Chang-Hyuk Choi, Jae-Sung Seo, Kyung-Jin Seo, Sang-Hun Ko, and Jin-Young.

Recommendation 1: Defining & Diagnosing UPIA. Learning Objectives State the definition of Undifferentiated Peripheral Inflammatory Arthritis (UPIA) Describe.

From: Treatment of Very Early Rheumatoid Arthritis With Symptomatic Therapy, Disease-Modifying Antirheumatic Drugs, or Biologic AgentsA Cost-Effectiveness.

FRAX & ITS ASSOCIATIONS IN RHEUMATOID ARTHRITIS

Immunohistochemical (IHC) staining for CD68/CD21 and CD3/CD20 on synovial tissue (ST) of patients with inflammatory bowel disease (IBD) with onset of peripheral.

Vibeke Strand, MD, MACR, Jasvinder A. Singh, MD, MPH

Diagnosing Rheumatoid Arthritis Early

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Chest radiograph of a 60 year old man, with rheumatoid arthritis and progressive dyspnoea, showing signs of fibrosing alveolitis with basal volume loss.

(A) Lequesne index and quadriceps strength of patients with knee OA

Immunohistochemical (IHC) staining for CD117 on synovial tissue (ST) of patients with inflammatory bowel disease (IBD) with onset of peripheral arthritis.

Hydroxychloroquine & Lupus

Updated 2016 PsA Core Domain Set.

Mean DAS (A), HAQ (B) and percentages in low disease activity, DAS remission and drug-free DAS remission (C) during 5 years in the DAS ≤2.4 steered (BeSt)

Kaplan-Meier survival plots for survival without: (A) progression to RA according to the number of joints with significant synovitis defined by GS≥ grade.

Effect of confidence interval reduction to demonstrate a true difference in means. Effect of confidence interval reduction to demonstrate a true difference.

Clinical, functional and radiographic outcomes following up to 3 years of open-label adalimumab as monotherapy after 2 years of adalimumab+methotrexate.

Nat. Rev. Cardiol. doi: /nrcardio

The severity of fatigue over 8 years of disease in early rheumatoid arthritis patients. The severity of fatigue over 8 years of disease in early rheumatoid.

Nowak et al. Am J Nephrol 2016;44: (DOI: / )

Factors influencing the relationship between disease activity (as measured with the ASDAS) and radiographic progression (as measured with the 2-year mSASSS.

Relationships between the baseline disease activity scores and scintigraphic sum scores for the patients with RA, pSpA and axSpA. Relationships between.

Different treatment strategies in rheumatoid arthritis in relation to radiographic progression (A) number of swollen joints (B) and fatigue severity over.

Fatigue severity across early patients with arthritis with different diagnoses at disease onset (A) and over 3 years of disease (B). Fatigue severity across.

Different scenarios that explain the effect that an external factor (here occupational activity—blue collar vs white collar—used as an example) could hypothetically.

The association between alcohol consumption and the severity of MRI-detected inflammation in hand and foot joints of (A) patients with RA and (B) asymptomatic.

Matrix risk model showing the probability of SRP in patients with moderate disease activity after 3 years of MTX treatment. Matrix risk model showing the.

Multivariate analysis for SRP after 3 years in patients with moderate disease activity despite MTX treatment. Multivariate analysis for SRP after 3 years.

Clinical response in patients with early and established RA at month 24. *p

Step-down efficacy through week 48: categorical CDAI state DMARD-IR (RA-BEAM, RA-BUILD, RA-BEACON) analysis set. Step-down efficacy through week 48: categorical.

Percentage of patients with RA achieving DAS28(CRP)<2

Involvement of the frontal and parietal lobes in patients with isolated cortical hyperintensities. Involvement of the frontal and parietal lobes in patients.

Percentage of patients achieving 20% improvement in the American College of Rheumatology criteria at week 12 by patient demographic and disease characteristics.

Acute Phase Reactants in Patients with UPIA

Ultrasonographic characteristics and synovitis pattern of patients with inflammatory bowel disease (IBD) with onset of peripheral arthritis under tumour.

Patient disposition after 2 years of treatment.

Study design. *Randomisation stratified by corticosteroid use at baseline. Study design. *Randomisation stratified by corticosteroid use at baseline. DAS28-CRP,

Satisfaction with control of RA

Fig. 2. Findings are compatible with rheumatoid arthritis (RA) on additional blood pool phase and bone phase of patients with RA. Increased blood pool.

Distribution of NEWS in the community by service

Cardiovascular disease risk assessment capture rates in the NOCAR project, evaluated across diagnosis groups and participating centre. Cardiovascular disease.

Progression of autonomic symptoms including hypohidrosis (A), faintness (B), syncope (C), constipation (D), urinary dysfunction (E), and respiratory disturbance.

Patient-level radiographic progression of structural joint damage at year 1 and year 2 by original randomisation. Patient-level radiographic progression.

(A) JIA-ACR30/50/70/90 response rates by visit in part 1.

Joint pain location and severity.

Frequency distribution of the number of fulfilled classification criteria for RA (ACR 1987) in relation to the proportion of positive anti-CCP antibodies.

Mean disease activity score based on a 28-joint count (DAS28 (ESR)) (A), Clinical Disease Activity Index (CDAI) score (B) and Simplified Disease Activity.

Depiction of bone marrow oedema using different techniques

Serial determinations of both anti-chromatin and anti-dsDNA antibodies in a patient who developed lupus nephropathy during the study period, showing that.

Changes in non-classical (CD11b+CD14+CD163−CD16+) and classical (CD11b+CD14+CD163+CD16−) monocytes over time in patients with rheumatoid arthritis (RA)

Changes over time of the daily prednisone dose in patients that responded to anakinra. Changes over time of the daily prednisone dose in patients that.

Presentation transcript:

Window of Opportunity in RA Radiographic progression occurs early and continues over the lifetime of a patient 70% of patients have radiographic damage within the first 3 years PCP 800,000 Rheums 725,000 Severe functional decline Radiographic damage Work disability Premature death Disease onset ♀ Zhu A&R 2011;63:3136 Zhang. ARD 2013 Jan 23 Taylor. Am J Med. 2012;125:1126 Zhang. A&R 2012;64:4004 Choi H. BMJ. 2012;12;344 Kuo CF. Joint Bone Spine. 2012;79:375. DeVera Arthritis Rheum. 2008;59:1549 Critical window of opportunity O’Dell JR. Arthritis Rheum. 2002;46:283-285. Editorial. Landewe RBM, et al. Arthritis Rheum. 2002;46:347-356.