Figure 3 Neural crest cell migration Figure 3 | Neural crest cell migration. Cardiac neural crest cells (green dots) migrate from the neural crest to the right ventricular outflow tract, large vessels, and surrounding structures. Brugada syndrome might be linked to an abnormal expression of the neural crest during embryological development of these structures. Reprinted from Elizari, M. V. et al. Abnormal expression of cardiac neural crest cells in heart development: a different hypothesis for the etiopathogenesis of Brugada syndrome. Heart Rhythm 4, 359–365 (2007), with permission from Elsevier. Reprinted from Elizari, M. V. et al. Abnormal expression of cardiac neural crest cells in heart development: a different hypothesis for the etiopathogenesis of Brugada syndrome. Heart Rhythm 4, 359–365 (2007), with permission from Elsevier Sieira, J. et al. (2016) Pathogenesis and management of Brugada syndrome Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.143