Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

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Presentation transcript:

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim CD73+ tumor cells (5 × 105) were injected into C57BL/6 WT (A), IFNγ−/− (B), or perforin−/− (C) mice. Mice were treated i.p. at days 14, 18, 22, and 26 with either isotype control (2A3; 200 μg/mouse) or anti–PD-1 mAb (RMP1-14, 200 μg/mouse) and where indicated SCH58261 (1 mg/kg) or vehicle control at days 14 to 29. Data represented as mean ± SEM of n = 6-7. n.s., not statistically significant; **, P < 0.01; ***, P < 0.001. Paul A. Beavis et al. Cancer Immunol Res 2015;3:506-517 ©2015 by American Association for Cancer Research