Supplementary Figure 4 a b c d e f

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Supplementary Figure 4 a b c d e f NES 1.780 NOM p-val 0.001 FDR q-val 0.006 NES 1.524 NOM p-val 0.0139 FDR q-val 0.053 c d BC-1 GTO 41.6% 58.4% Relative XAF1 mRNA Relative XAF1 mRNA e f BC-1 GTO BC-1 GTO Relative OAS1 mRNA Relative OAS1 mRNA Relative TRAIL mRNA Relative TRAIL mRNA Supplementary Figure 4. GSEA plots revealing significant positive enrichment of gene expression signatures of apoptosis (a) and p53 pathway (b) derived from a database (http://software.broadinstitute.org/gsea/msigdb) in PU.1-up-regulated BCBL-1 cells compared with control cells. (c) The ratio of up-regulated ISGs among at least two-fold increased genes in the microarray analysis. XAF1 (d), OAS1 (e), and TRAIL (f) mRNA expression levels were measured by quantitative RT-PCR. BC-1 and GTO cells that expressed Dox-inducible PU.1 were treated with 1.0 μg/ml Dox for 0, 24, and 48 h. Values are the mean ± SD (n =3).