Volume 9, Issue 10, Pages 986-994 (October 2010) Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study  Aleksey Shatunov, PhD, Kin Mok, MSc, Stephen Newhouse, PhD, Michael E Weale, PhD, Bradley Smith, PhD, Caroline Vance, PhD, Lauren Johnson, PhD, Jan H Veldink, MD, Michael A van Es, MD, Prof Leonard H van den Berg, MD, Prof Wim Robberecht, MD, Philip Van Damme, MD, Prof Orla Hardiman, MD, Prof Anne E Farmer, FRCPsych, Prof Cathryn M Lewis, PhD, Amy W Butler, PhD, Olubunmi Abel, MSc, Prof Peter M Andersen, MD, Isabella Fogh, PhD, Prof Vincenzo Silani, MD, Adriano Chiò, MD, Bryan J Traynor, MD, Prof Judith Melki, MD, Prof Vincent Meininger, MD, John E Landers, PhD, Prof Peter McGuffin, FRCPsych, Jonathan D Glass, MD, Hardev Pall, MD, Prof P Nigel Leigh, FMedSci, Prof John Hardy, PhD, Prof Robert H Brown, DPhil, John F Powell, DPhil, Richard W Orrell, MD, Prof Karen E Morrison, DPhil, Prof Pamela J Shaw, MD, Prof Christopher E Shaw, MD, Prof Ammar Al-Chalabi, PhD  The Lancet Neurology  Volume 9, Issue 10, Pages 986-994 (October 2010) DOI: 10.1016/S1474-4422(10)70197-6 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 p values for association in the independent genome-wide association study The Lancet Neurology 2010 9, 986-994DOI: (10.1016/S1474-4422(10)70197-6) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 p values for association in the joint analysis The Lancet Neurology 2010 9, 986-994DOI: (10.1016/S1474-4422(10)70197-6) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Genetic architecture of the associated region Circles=−log10 of the p value of association with amyotrophic lateral sclerosis for typed and imputed single nucleotide polymorphisms in the joint analysis, coloured according to linkage disequilibrium with rs3849942 (shown as a purple diamond) as measured by r2. Blue lines=recombination rate across the locus based on the 1000 genomes project. Genes in the region are displayed below the graph. Arrows indicate the direction of transcription. The Lancet Neurology 2010 9, 986-994DOI: (10.1016/S1474-4422(10)70197-6) Copyright © 2010 Elsevier Ltd Terms and Conditions