M. Murata, M.D., Ph.D., K. Yudoh, M.D., Ph.D., K. Masuko, M.D., Ph.D.

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Presentation transcript:

The potential role of vascular endothelial growth factor (VEGF) in cartilage M. Murata, M.D., Ph.D., K. Yudoh, M.D., Ph.D., K. Masuko, M.D., Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 3, Pages 279-286 (March 2008) DOI: 10.1016/j.joca.2007.09.003 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Vascular supply in the growth plate (based on Ref. 1). Osteoarthritis and Cartilage 2008 16, 279-286DOI: (10.1016/j.joca.2007.09.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Hypothetical kinetics of VEGF expression in human articular chondrocytes. During growth plate development (“the growth phase”), VEGF is expressed in chondrocytes playing a pivotal role in cartilage growth and endochondral ossification. In adult cartilage (“the mature phase”), expression of angiogenic factors is suppressed and blood vessel invasion is also almost completely suppressed, leaving mature cartilage avascular. Upon exposure to pathological stimulation such as inflammation or accumulating mechanical stress, VEGF would be re-upregulated in hypertrophic chondrocytes. Although the fate of VEGF expression in stressed chondrocytes has always been unclear, higher levels of VEGF expression in OA than in normal chondrocytes have been reported. Arbitrary levels of VEGF expression in chondrocytes are shown in the drawing. Osteoarthritis and Cartilage 2008 16, 279-286DOI: (10.1016/j.joca.2007.09.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 The potential role of VEGF in OA (hypothesis). VEGF could be induced by an array of catabolic triggers in chondrocytes, and the expressed VEGF might affect these chondrocytes, e.g., via angiogenesis leading to osteophyte formation, via induction of matrix proteases, or via regulation of cellular viability through Bcl-2 activation. Osteoarthritis and Cartilage 2008 16, 279-286DOI: (10.1016/j.joca.2007.09.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions