Triglyceride Metabolism under Attack

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Presentation transcript:

Triglyceride Metabolism under Attack Sander Kersten Cell Metabolism Volume 25, Issue 6, Pages 1209-1210 (June 2017) DOI: 10.1016/j.cmet.2017.05.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Autoantibodies against GPIHBP1 Provoke Hyperchylomicronemia Left panel: metabolism of triglyceride-rich lipoproteins under normal circumstances. LPL is produced by adipocytes and myocytes and transported from the surface of these cells to the capillary lumen by GPIHBP1. Right panel: autoantibodies against GPIHBP1 prevent the transport of LPL to the capillary lumen. The resultant functional LPL deficiency leads to impaired clearance of triglyceride-rich lipoproteins, causing hyperchylomicronemia. LPL, lipoprotein lipase; GPIHBP1, glycosylphosphatidylinositol-anchored HDL binding protein 1; HSPG, heparan sulfate proteoglycan; TG, triglycerides. Cell Metabolism 2017 25, 1209-1210DOI: (10.1016/j.cmet.2017.05.005) Copyright © 2017 Elsevier Inc. Terms and Conditions