Claudia Sala, David C. Grainger, Stewart T. Cole Cell Host & Microbe

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Dissecting Regulatory Networks in Host-Pathogen Interaction Using ChIP-on-chip Technology Claudia Sala, David C. Grainger, Stewart T. Cole Cell Host & Microbe Volume 5, Issue 5, Pages 430-437 (May 2009) DOI: 10.1016/j.chom.2009.04.007 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of the ChIP-on-chip Technology Cells are crosslinked with formaldehyde in order to introduce reversible covalent bonds between proteins and DNA. After cell lysis and shearing of DNA, the protein of interest is immunoprecipitated together with bound DNA fragments, which are then decrosslinked, purified, labeled, and hybridized to microarrays. Finally, after scanning, ChIP-on-chip signals are plotted against genome coordinates to visualize the protein binding sites. Cell Host & Microbe 2009 5, 430-437DOI: (10.1016/j.chom.2009.04.007) Copyright © 2009 Elsevier Inc. Terms and Conditions