Neglected fungal zoonoses: hidden threats to man and animals S. Seyedmousavi, J. Guillot, A. Tolooe, P.E. Verweij, G.S. de Hoog  Clinical Microbiology and Infection  Volume 21, Issue 5, Pages 416-425 (May 2015) DOI: 10.1016/j.cmi.2015.02.031 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Clinical manifestations and laboratory features of lobomycosis in humans. Reproduced from reference Paniz-Mondolfi et al. 2012 [38] with permission of the publisher. Keloid-like lesions over the upper limb of a patient with lobomycosis (a); multiple confluent papules, plaques and nodule lesions admixed with small verrucous areas on the foot of a patient with lobomycosis (b, c); Grocott methamine silver-stained section showing multiple isolated and chained yeasts (magnification × 40) (d). Clinical Microbiology and Infection 2015 21, 416-425DOI: (10.1016/j.cmi.2015.02.031) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Clinical manifestations and laboratory features of lobomycosis in a dolphin. Reproduced from reference Paniz-Mondolfi et al. 2012 [38] with permission of the publisher. Extensive white greyish proliferating lesions with keloidal and verrucous aspect forming rosettes on the dorsal (a), flanks (b) and fin (c) of a dolphin; Grocott methamine silver-stained section from a skin biopsy specimen of a dolphin showing abundant yeast cells individually and in chains connected by thin tubular bridges (magnification ×400) (d). Clinical Microbiology and Infection 2015 21, 416-425DOI: (10.1016/j.cmi.2015.02.031) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Clinical manifestations and laboratory features of paracoccidioidomycosis in humans. Reproduced from reference Ameen et al. 2010 [72] with permission of the publisher. Ulcerative lesion with punctate haemorrhagic dots (a); dissemination to the skin, presenting as erythematous papules and plaques, some of which are beginning to ulcerate (b); centrofacial cutaneous and mucosal ulcerative lesions (c); chest radiograph depicting diffuse bilateral nodular opacities in pulmonary Paracoccidioidomycosis (d); direct microscopy of a skin scraping detects fungal cells of paracoccidioidomycosis with thick bi-refringent walls (magnification × 40) (e); splenic tissue showing the characteristic ‘ship-pilot's wheel’ (magnification × 40) (f). Clinical Microbiology and Infection 2015 21, 416-425DOI: (10.1016/j.cmi.2015.02.031) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 Clinical manifestations and laboratory features of paracoccidioidomycosis in a dog. Reproduced from reference de Farias et al. 2011 [75] with permission of the publisher. Generalized lymphadenomegaly in submandibular lymph node (a); prescapular lymph node (b); inguinal lymph node (c); popliteal lymph node (d); histological fragment of popliteal lymph node stained with haematoxylin & eosin showing oval structures (e) and stained with periodic acid–Schiff showing the same poorly stained oval structure surround by neutrophils, macrophages and giant cells (f). Clinical Microbiology and Infection 2015 21, 416-425DOI: (10.1016/j.cmi.2015.02.031) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions