Volume 49, Issue 6, Pages (December 2013)

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Volume 49, Issue 6, Pages 424-430 (December 2013) Automatically Quantified Diffuse Excessive High Signal Intensity on MRI Predicts Cognitive Development in Preterm Infants Nehal A. Parikh, DO MS, Lili He, PhD, Eliana Bonfante-Mejia, MD, Leo Hochhauser, MD, Patricia Evans Wilder, MD, Katrina Burson, RN, Supreet Kaur, MS Pediatric Neurology Volume 49, Issue 6, Pages 424-430 (December 2013) DOI: 10.1016/j.pediatrneurol.2013.08.026 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Representative examples of varying degrees of diffuse excessive high signal intensity detected using our automated segmentation method. Raw axial T2-weighted images (left column) and mean diffusivity maps in the centrum semiovale with segmented diffuse excessive high signal intensity highlighted in blue (right column), display representative examples of mild (top panel), moderate (middle), and severe diffuse excessive high signal intensity (lower panel). Pediatric Neurology 2013 49, 424-430DOI: (10.1016/j.pediatrneurol.2013.08.026) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Linear regression plots demonstrate relationship between diffuse excessive high signal intensity (DESHI) measures and developmental scores. Regression plots display linear relationships between DEHSI measures, volume (top panel), mean diffusivity (MD) sum (second panel), axial diffusivity (AD) sum (third panel), and radial diffusivity (RD) sum (lowest panel), and Bayley Scales of Infant and Toddler Development III cognitive (left column) and language scores (right column) at 2 years of age. Pediatric Neurology 2013 49, 424-430DOI: (10.1016/j.pediatrneurol.2013.08.026) Copyright © 2013 Elsevier Inc. Terms and Conditions