Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis Aaron M. Hosios, Matthew G. Vander Heiden  Developmental Cell  Volume 40, Issue 2, Pages 118-119 (January 2017) DOI: 10.1016/j.devcel.2017.01.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Sources and Uses of Acetyl-CoA in Mammalian Cells Fatty acids, glucose, amino acids, and acetate can all serve as sources of acetyl-CoA. To produce acetyl-CoA from fatty acids, fatty acyl-CoA must be transported into the mitochondrial matrix, requiring enzymes CPT1 and CPT2, as shown. Fatty acyl-CoA in the mitochondrial matrix can undergo β-oxidation to produce acetyl-CoA. Mitochondrial acetyl-CoA can enter the TCA cycle to be further oxidized to CO2 for energy generation, or it can be exported to the cytosol (as citrate) for use in biosynthesis or for acetylation reactions. Developmental Cell 2017 40, 118-119DOI: (10.1016/j.devcel.2017.01.004) Copyright © 2017 Elsevier Inc. Terms and Conditions