Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study C.J Glueck, M.D., Harvey Phillips, M.D., Dan Cameron, M.D., Luann Sieve-Smith, B.A., Ping Wang, Ph.D. Fertility and Sterility Volume 75, Issue 1, Pages 46-52 (January 2001) DOI: 10.1016/S0015-0282(00)01666-6
Figure 1 Current (during metformin therapy) and previous (while not receiving metformin) first-trimester spontaneous abortions and live births in 10 women with the polycystic ovary syndrome who had 22 previous pregnancies. P<.002, Fisher exact test. Glueck. Metformin throughout pregnancy and PCOS. Fertil Steril 2001. Fertility and Sterility 2001 75, 46-52DOI: (10.1016/S0015-0282(00)01666-6)