9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk Qin Xiao, MA, Shan Gao, PhD, Hui Luo, MD, Wenguo.

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9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk Qin Xiao, MA, Shan Gao, PhD, Hui Luo, MD, Wenguo Fan, PhD, MD, Shicheng Guo, PhD, Hong Yao, PhD, Shuilong Leng, PhD, MD, Zhenhua Xu, PhD, Tao Tao, PhD, MD, Xingyan Liu, PhD, MD, Zhang Jingfang, PhD, Ming Zhang, MA, Dongpei Li, PhD, MD, Qin Xiao, MD Journal of Thoracic Oncology Volume 9, Issue 7, Pages 1041-1047 (July 2014) DOI: 10.1097/JTO.0000000000000195 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 The case-control association, Q-Q plot and linkage disequilibrium in the discovery study. A, the results (−log10 of p values) of the association of single-nucleotide polymorphisms (SNPs) with S. japonicum infection on 9q33.3. (B) Q-Q plot for the test statistics of observed χ2 values against expected χ2 values. (C) Q-Q plot for the test statistics of observed χ2 values against expected χ2 values removing the rs10118570. (D) Linkage disequilibrium mapping. The block 1 encompasses the promoter of PSMB7 to the seventh intron of GPR144 and is 36 kb; block 2 includes the 5′ UTR and promoter of GRP78 and is only 236bp; block 3 extends near 16.5kb from FAM125B promoter to its first intron. The blue ellipse indicates the potential SNP that not belongs to any block. Journal of Thoracic Oncology 2014 9, 1041-1047DOI: (10.1097/JTO.0000000000000195) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions