Volume 137, Issue 2, Pages 502-511 (August 2009) Time Trends in Therapies and Outcomes for Adult Inflammatory Bowel Disease, Northern California, 1998–2005  Lisa J. Herrinton, Liyan Liu, Bruce Fireman, James D. Lewis, James E. Allison, Nicole Flowers, Susan Hutfless, Fernando S. Velayos, Oren Abramson, Andrea Altschuler, Geraldine S. Perry  Gastroenterology  Volume 137, Issue 2, Pages 502-511 (August 2009) DOI: 10.1053/j.gastro.2009.04.063 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Conceptual model: predictors, patterns of care, and outcomes. Gastroenterology 2009 137, 502-511DOI: (10.1053/j.gastro.2009.04.063) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Time trends in rates of visits to gastroenterology (GI) and primary care (PCP) physicians. CD, Crohn's disease; UC, ulcerative colitis. Gastroenterology 2009 137, 502-511DOI: (10.1053/j.gastro.2009.04.063) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 (A) Time trends in supply (months/patient-year) of 5-aminosalicylate (5-ASA), immunomodulator (IM), and steroid (left axis) and infliximab prevalence (right axis) for Crohn's disease. All results were adjusted for patient factors (age, sex, race or ethnicity, and comorbidity). P values are shown in the legend. (B) Time trends in supply (months/patient-year) of oral 5-ASA (left axis), and IM, oral steroid, rectal 5-ASA, and rectal steroid (right axis) for ulcerative colitis. “Other drug supply” is all drugs except oral 5-ASA, which is shown on the left axis. All results were adjusted for patient factors (age, sex, race or ethnicity, and comorbidity). All P values for differences across time were significant at <.0001. Gastroenterology 2009 137, 502-511DOI: (10.1053/j.gastro.2009.04.063) Copyright © 2009 AGA Institute Terms and Conditions

Figure 4 (A) Time trends in the prevalence of prolonged steroid exposure and in the rates of hospitalization and surgery for Crohn's disease. All results were adjusted for patient factors (age, sex, race or ethnicity, and comorbidity). P values are shown in the key. (B) Time trends in prevalence of prolonged steroid exposure, and in the rates of hospitalization and surgery (× 10) for ulcerative colitis. All results were adjusted for patient factors (age, sex, race or ethnicity, and comorbidity). P values are shown in key. Gastroenterology 2009 137, 502-511DOI: (10.1053/j.gastro.2009.04.063) Copyright © 2009 AGA Institute Terms and Conditions