Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome  Ulrich Wahnschaffe, R. Ullrich, E.O. Riecken, J.D. Schulzke  Gastroenterology  Volume 121, Issue 6, Pages 1329-1338 (December 2001) DOI: 10.1053/gast.2001.29572 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 (A) IgM antibody concentration against gliadin, tissue-transglutaminase, β-lactoglobulin, and ovalbumin corrected for total IgM concentration in duodenal aspirate of untreated cd patients (ucd), treated cd patients (tcd), and patients with latent cd (lcd) and IBS. (B) IgA antibody concentration against gliadin, tissue-transglutaminase, β-lactoglobulin, and ovalbumin corrected for total IgA concentration in duodenal aspirate. Values greater than 2 SD above the mean of the controls were considered as increased (solid line indicates this normal range). Numbers of patients with increased values per numbers of patients tested are indicated along the abscissa. Gastroenterology 2001 121, 1329-1338DOI: (10.1053/gast.2001.29572) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 IELs per 100 enterocytes in patients with ucd, tcd, lcd, and IBS. More than 40 lymphocytes per 100 enterocytes were considered to be elevated. Values greater than 2 SD above the mean of the controls were considered as increased (solid line indicates this normal range). Numbers of patients with increased values per numbers of patients tested are indicated along the abscissa. Gastroenterology 2001 121, 1329-1338DOI: (10.1053/gast.2001.29572) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Frequencies of increased IgA antibodies against gliadin and/or tissue-transglutaminase in (left) duodenal aspirate and (right) increased IEL in patients with ucd, tcd, lcd, and IBS. Both markers were more frequent in HLA DQ2–positive IBS patients than in HLA DQ2–negative IBS patients. Statistical comparisons were done by the chi-squared test. Gastroenterology 2001 121, 1329-1338DOI: (10.1053/gast.2001.29572) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Changes (Δ) in (A) stool frequency, (B) intestinal IgA antibody titers against tissue-transglutaminase, and/or gliadin, and (C) IEL counts in 26 IBS patients after 6 months of gluten-free diet. Gastroenterology 2001 121, 1329-1338DOI: (10.1053/gast.2001.29572) Copyright © 2001 American Gastroenterological Association Terms and Conditions