T2DM Management
Program Overview
The Development of Basal Insulins
Continuum of Clinical Research: RCTs and RWE
BEGIN and EDITION Trials for Deg-100 and Gla-300
RWE for Gla-300: DELIVER Studies
DEVOTE Trial: Deg-100 vs Gla-100
Comparing PK/PD Data
Cannot Directly Compare BEGIN and EDITION Programs
BRIGHT: Head-to-Head Comparison of Gla-300 and Deg-100
BRIGHT: Study Endpoints and Glycemic Targets
BRIGHT: Baseline Characteristics
BRIGHT: Primary Endpoint: Glycemic Control
BRIGHT: FPG and SMBG Reduction
BRIGHT: 8-Point SMBG and Variability Profiles
BRIGHT: Anytime (24 h) Hypoglycemia
BRIGHT: Nocturnal (00:00–06:00 h) Hypoglycemia
BRIGHT: TEAEs
BRIGHT: Insulin Dosage and Body Weight Over 24 Weeks
BRIGHT: Results Summary
Conclusions
Abbreviations
Abbreviations (cont)