Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model Paul M. Petre, MDa, Frank A. Baciewicz, MDb, Stefan.

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Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model Paul M. Petre, MDa, Frank A. Baciewicz, MDb, Stefan Tigan, PhDd, J.Richard Spears, MDc The Journal of Thoracic and Cardiovascular Surgery Volume 125, Issue 1, Pages 85-95 (January 2003) DOI: 10.1067/mtc.2003.90 Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 HBO effect on embryonic cardiac myocyte (H9C2) growth curves. Diamonds indicate normal growth curve in air; squares indicate reduced growth with toxic effect of HBO. Data points represent mean; error bars represent SE; number of observations = 29. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 HBO effect on rat sarcoma cell (MCA-2) growth curves. Triangles indicate normal growth curve in air; circles indicate increased growth after 1.5 hours HBO for up to 36 hours. Data points represent mean; error bars represent SE; number of observations = 28. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Dose-dependent responses of embryonic cardiac myocytes (H9CA) and sarcoma cells (MCA-2) to doxorubicin. A, Cell death of H9C2 cells even at minimal doxorubicin doses. B, LDH activity in H9C2 cells (which mirrors cell death) showed increasing activity with increasing doxorubicin doses. C, Cell death of MCA-2 cells even at minimal doxorubicin doses. D, LDH activity in MCA-2 cells (which mirrors cell death) showed increasing activity with increasing doxorubicin doses. Ctr, Control; m, micromolar; c%, concentration. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 HBO as chemosensitizer. Cell counts with 1.5 hours of pretreatment HBO show enhanced sarcoma cell (MCA-2) death relative to treatment of sarcoma cells with doxorubicin only or pretreatment with 3.5 hours of HBO. d, Micromolar doxorubicin dose. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Mitomycin effect on sarcoma cells (MCA-2) treated with HBO and doxorubicin. Mitomycin blocks HBO-induced proliferation. There is no significant difference between doxorubicin-treated cells and cells treated with mitomycin before HBO and doxorubicin administration. Horizontal line fill, Doxorubicin only at 0.2 μmol/L; gray fill, doxorubicin plus HBO; dotted fill, doxorubicin and HBO with mitomycin pretreatment. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 PA Po2 after HBO administration by hyperbaric chamber. Note increases in PA Po2 at 10 (10′) and 30 minutes (30′) relative to baseline. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 In vivo response to doxorubicin and HBO in rat metastatic lung sarcoma model. A, Number of metastases per individual lung decreased significantly when treated with doxorubicin (Doxo) alone and then had significant further decrease when treated with HBO and doxorubicin. B, Changes in individual lung weights correspond with decreases in metastatic tumor nodules. No treat., No treatment; Ctr, control. The Journal of Thoracic and Cardiovascular Surgery 2003 125, 85-95DOI: (10.1067/mtc.2003.90) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions