Lifelong patterns of BMI and cardiovascular phenotype in individuals aged 60–64 years in the 1946 British birth cohort study: an epidemiological study

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Presentation transcript:

Lifelong patterns of BMI and cardiovascular phenotype in individuals aged 60–64 years in the 1946 British birth cohort study: an epidemiological study Marietta Charakida, PhD, Tauseef Khan, PhD, William Johnson, PhD, Prof Nick Finer, MD, John Woodside, PhD, Prof Peter H Whincup, PhD, Prof Naveed Sattar, MBChB, Prof Diana Kuh, PhD, Prof Rebecca Hardy, PhD, Prof John Deanfield, MB BChir The Lancet Diabetes & Endocrinology Volume 2, Issue 8, Pages 648-654 (August 2014) DOI: 10.1016/S2213-8587(14)70103-2 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Patient flow diagram cIMT=carotid intima media thickness. *13 (4%) of 328 people had plaques. The Lancet Diabetes & Endocrinology 2014 2, 648-654DOI: (10.1016/S2213-8587(14)70103-2) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Patterns of BMI change in adulthood and cIMT at age 60–64 years Data expressed as mean cIMT and 95% CI for each BMI group. Test for trend for O/O since 1982 to O/O since 09: p<0·0001. Pairwise comparison of never O/O versus O/O: p=0·68 since 2009; p=0·033 since 1999; p=0·012 since 1989; p<0·0001 since 1982; and lost and gained, p=0·73. Comparison of never lost weight (composite of O/O since 2009, since 1999, since 1989 and 1982) versus: lost and gained, p=0·002; and never O/O, p=0·001. O/O=overweight or obese. *17 participants lost weight and did not regain it. The Lancet Diabetes & Endocrinology 2014 2, 648-654DOI: (10.1016/S2213-8587(14)70103-2) Copyright © 2014 Elsevier Ltd Terms and Conditions