Volume 97, Issue 4, Pages (August 2009)

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Volume 97, Issue 4, Pages 1198-1205 (August 2009) Structural Characterization of Edematous Corneas by Forward and Backward Second Harmonic Generation Imaging Chiu-Mei Hsueh, Wen Lo, Wei-Liang Chen, Vladimir A. Hovhannisyan, Guang-Yu Liu, Sheng-Shun Wang, Hsin-Yuan Tan, Chen-Yuan Dong Biophysical Journal Volume 97, Issue 4, Pages 1198-1205 (August 2009) DOI: 10.1016/j.bpj.2009.05.040 Copyright © 2009 Biophysical Society Terms and Conditions

Figure 1 Experimental setup of the SHG microscope. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 2 Photographs of normal and edematous corneas. En face (top) and side (bottom) views are shown. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 3 Demonstration of the lamella thickness measurement method using en face FWSHG images of normal bovine cornea at different depths. The first to last images show the appearance and disappearance of collagen fibril with a given orientation. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 4 Large-area morphological comparison in the x-y plane between normal and edematous bovine corneas at depths of 100 μm (top) and 1000 μm (bottom) measured in the anterior–posterior direction. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 5 Stacks of FWSHG and BWSHG images with a total thickness of 1000 μm from both the anterior–posterior and posterior–anterior directions in the normal (A, B, E, and F) and edematous (C, D, G, and H) groups. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 6 Depth-resolved en face SHG images of an image stack from Fig. 5, A–D, respectively. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 7 Depth dependence of normalized FWSHG (A) and BWSHG (B) intensities in three different normal (N1, N2, and N3) and edematous (E1, E2, and E3) corneas in the anterior–posterior direction. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions

Figure 8 Histograms of the depth-dependent, corneal lamella thickness (mean ± SD) comparison between normal (A) and edematous (B) corneas. Biophysical Journal 2009 97, 1198-1205DOI: (10.1016/j.bpj.2009.05.040) Copyright © 2009 Biophysical Society Terms and Conditions