Renée Sananes, PhD, Cedric Manlhiot, BS, Edmond Kelly, MD, Lisa K

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Neurodevelopmental Outcomes After Open Heart Operations Before 3 Months of Age Renée Sananes, PhD, Cedric Manlhiot, BS, Edmond Kelly, MD, Lisa K. Hornberger, MD, William G. Williams, MD, Daune MacGregor, MD, Raymond Buncic, MD, Brian W. McCrindle, MD, MPH The Annals of Thoracic Surgery Volume 93, Issue 5, Pages 1577-1583 (May 2012) DOI: 10.1016/j.athoracsur.2012.02.011 Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Patient flow chart. The Annals of Thoracic Surgery 2012 93, 1577-1583DOI: (10.1016/j.athoracsur.2012.02.011) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Distribution of Peabody Developmental Motor Scales (PDMS) raw scores and percentile score across all 3 assessments. Average change over time was +0.593 (0.131) points per month (p < 0.001) for gross motor scale and −0.392 (0.120) points per month (p = 0.001) for fine motor scale. (DMQ = developmental motor quotient.) The Annals of Thoracic Surgery 2012 93, 1577-1583DOI: (10.1016/j.athoracsur.2012.02.011) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Proportion of abnormal scores on the ASQ across all 3 assessments. Odds ratio for abnormal scores increased over time for all dimensions: communication (odds ratio [OR], 0.959/month; p = 0.04), gross motor (OR, 0.966/month; p = 0.06), fine motor (OR, 0.942/month; p = 0.03), problem solving (OR, 0.897/month; p < 0.001), and personal-social (OR, 0.920/month; p < 0.001). (ASQ = Ages & Stages Questionnaire.) The Annals of Thoracic Surgery 2012 93, 1577-1583DOI: (10.1016/j.athoracsur.2012.02.011) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Neurodevelopmental classification according to MDI scores on BSID-II. Scores 85 to 114 are considered normal, 70 to 84 indicate mild developmental delay, less than 70 indicates severe developmental delay, and greater than or equal to 115 indicates accelerated development. (BSID-II = Bayley Scales of Infant Development, 2nd edition; MDI = Mental Development Index.) The Annals of Thoracic Surgery 2012 93, 1577-1583DOI: (10.1016/j.athoracsur.2012.02.011) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions