Gender Variance How does it occur When does it happen 1/17/2019

What is Gender? and What is Sex?  Sex biological classification "male" or "female" Gender psychological identification "man" or "woman" 1/17/2019

When does it begin? The very moment of conception Studies are continually shedding more light On how an embryo becomes male or female And how this process sometimes goes awry 1/17/2019

Several factors nudge the infant toward male or female development All embryos Are identical in external appearance for the first eight weeks Several factors nudge the infant toward male or female development 1/17/2019

In the seventh week the embryo has both male and female primordial ducts In the normal female fetus, the millerian duct system then develops into oviducts and a uterus 1/17/2019

Male In the normal male fetus, the wolferian duct system each side develops into the epididymis and vas deferens 1/17/2019

Genitalia The external genitalia are bipotential until the eighth week The reproductive organs and genitals associated with "female" or "male“ Come from the same initial (fetal) tissue The urogenital slit disappears and male genitalia form Or it remains open, and female genitalia form. 1/17/2019

If the Egg Fertilized with the x chromosome female structures continue to mature The default system. Fertilized with the y chromosome A hormonal switch occurs Two genes are activated and the female structures are completely dissolved The male organs take their place. 1/17/2019

Some embryos step off track. Rat mothers placed in stress during the equivalent of the first trimester Have rat sons with female (Lordic) behavior. 1/17/2019

Fetal Endocrine Effects due to endocrine disrupting chemicals Occur in concentrations as low as parts per trillion The fetal endocrine system is more sensitive to disruption than any other known body system. Hormones from an external source Many commonly used chemicals and materials Are estrogenic, anti-estrogenic, androgenic, and anti-androgenic These chemicals can also affect enzymes which amplify the effect of hormones 1/17/2019

Disruptors Endocrine disruptors in the fetus Change this "correct" value to Some value which is not programmed by genetics. Chemicals modulate (up or down) the reception or secretion of hormones in any of these glands Change the concentrations of hormones which have been programmed by genetics Which are produced by the fetus during development. 1/17/2019

Disrupting Chemicals Endocrine disrupting chemicals Behave much like natural hormones But interfering signals result in erroneous decisions at the cellular level The cell's receptors accept both endocrine disruptors and natural hormones as valid signals Communication between the central nervous system and cells of the body In part, controlled by hormones which act as chemical messengers to direct the activity of cells. 1/17/2019

Exposure to Chemicals Exposure to a wide variety of endocrine disrupting chemicals Present in the environment Produce disruptions to the fetal endocrine system Which produce numerous developmental anomalies Including varying degrees of gender dysphoria And intersex conditions 1/17/2019

Intersexual There are 72 recognized conditions Only some have ambiguous genetaila Include those that are with out gene mapping undetectable Can include those that are XYY, XXY, XXYY 1/17/2019

Gender Variants Can Include CD Crossdressers, those that wear the clothing of the other sex Equally male and female (dual gender) TG transgenderist Generally spend more time in opposite sex role TS Transsexuals Gender is the opposite of birth sex 1/17/2019

Are there any other transgendered people in your family? Population Are there any other transgendered people in your family?   Frequency Valid Percent Cumulative Percent Valid yes 15 13.6 no 49 44.5 58.2 unknown/don't know 43 39.1 97.3 Total 110 100 1/17/2019

Gender Variance Identity   Frequency Valid Percent Cumulative Percent Valid crossdresser 28 25.5 transvestite 2 1.8 27.3 transgendered 19 17.3 44.5 non-op transsexual 6 5.5 50 pre-op transsexual 17 15.5 65.5 Post op transsexual 22 20 85.5 other 13 11.8 97.3 Missing 3 2.7 100 Total 110 1/17/2019

Conclusion Most research points to a physiological reason For Gender Variance Who do you know that is? 1/17/2019

Who? Who they are 1/17/2019

The first evidence 1/17/2019