Getting to the heart of COX-2 inhibition

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Presentation transcript:

Getting to the heart of COX-2 inhibition Matthew D. Breyer Cell Metabolism Volume 2, Issue 3, Pages 149-150 (September 2005) DOI: 10.1016/j.cmet.2005.08.009 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Normally, increased dietary salt does not increase blood pressure, in part due to the protective effects of prostacyclin (PGI2) and IP receptor activation In mice lacking the IP receptor, increased BP and cardiac fibrosis ensue. The fibrosis depends on thromboxane-receptor activation since it does not occur in mice lacking the TP receptor. This pathway might contribute to the cardio-protective effects of low-dose aspirin, which inhibits thromboxane synthesis and injurious effects of COX-2 inhibitors, which in turn inhibits prostacyclin production. Cell Metabolism 2005 2, 149-150DOI: (10.1016/j.cmet.2005.08.009) Copyright © 2005 Elsevier Inc. Terms and Conditions