C. Kersten, M.G. Cameron, B. Laird, S. Mjåland

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Epidermal growth factor receptor – inhibition (EGFR-I) in the treatment of neuropathic pain C. Kersten, M.G. Cameron, B. Laird, S. Mjåland British Journal of Anaesthesia Volume 115, Issue 5, Pages 761-767 (November 2015) DOI: 10.1093/bja/aev326 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 (a–c) Changes in worst pain scores for individual patients, grouped according to aetiology of the neuropathic pain. Worst pain scores for individual patients pre-treatment (day 0) and for the first 13 post–treatment days. Numbers in the figures indicate case numbers, reflecting the order in which the patients were treated (see appendix). BC, bladder cancer; CC, cervical cancer; RCC, renal cancer; RC, rectal cancer; CIPN, chemotherapy (oxaliplatin) induced peripheral neuropathy; CRPS, complex regional pain syndrome type 1; HN, acute Herpes Zoster; PHN, post-herpetic neuralgia; PLP, phantom limb pain; PN, idiopathic peripheral neuropathy. See appendix for detailed narrative according to case numbers. British Journal of Anaesthesia 2015 115, 761-767DOI: (10.1093/bja/aev326) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Time to neuropathic pain recurrence after stopping EGFR-I. Panitumumab (blue bar) has an elimination half-life of 7.5 days (range: 3.6–10.9 days) [28] and its recommended administration interval is 14 days when given as an anti-cancer drug. The elimination half-life of cetuximab (green bar) ranges from 2.9 to 4.2 days [35] and for oncologic indications the drug is given every 7 to 14 days. For the oral agents, the elimination half-lives are 36 and 41 h for erlotinib (orange bar) [25] and gefitinib (pink bar) [24], respectively. FBSS, failed back surgery syndrome; HN, herpetic neuralgia; RC, rectal cancer; CC, cervical cancer; CRPS, complex regional pain syndrome type 1; CIPN, chemotherapy-induced peripheral neuropathy; *dose reduction of erlotinib from 150 to 100 mg. British Journal of Anaesthesia 2015 115, 761-767DOI: (10.1093/bja/aev326) Copyright © 2015 The Author(s) Terms and Conditions