Rad53 Cell Volume 115, Issue 5, Pages (November 2003)

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Presentation transcript:

Rad53 Cell Volume 115, Issue 5, Pages 508-510 (November 2003) Jean-Pierre Quivy, Geneviève Almouzni Cell Volume 115, Issue 5, Pages 508-510 (November 2003) DOI: 10.1016/S0092-8674(03)00931-0

Figure 1 Rad53 and the Maintenance of Histone Levels In this simplified model, newly synthesized histones, after their association with chaperones (step 1), provide a pool of histones available for deposition onto DNA (step 2). The available histones can interact dynamically with Rad53 (step3), which can promote histone degradation (step 4). In this way, a tightly regulated level of nonnucleosomal histones is maintained. Cell 2003 115, 508-510DOI: (10.1016/S0092-8674(03)00931-0)