Failure to elicit seroresponses to pneumococcal surface proteins (pneumococcal histidine triad D, pneumococcal choline-binding protein A, and serine proteinase.

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Presentation transcript:

Failure to elicit seroresponses to pneumococcal surface proteins (pneumococcal histidine triad D, pneumococcal choline-binding protein A, and serine proteinase precursor A) in children with pneumococcal bacteraemia A. Hagerman, K.M. Posfay-Barbe, S. Grillet, M.M. Ochs, R.H. Brookes, D. Greenberg, N. Givon-Lavi, R. Dagan, C.-A. Siegrist Clinical Microbiology and Infection Volume 18, Issue 8, Pages 756-762 (August 2012) DOI: 10.1111/j.1469-0691.2011.03629.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Fold-increase of anti-pneumococcal surface protein (PSP) antibody concentrations in bacteraemic children. The ratio of convalescent to acute anti-PSP antibody geometric mean concentration (GMC) is illustrated for each PSP and age group. PcpA, pneumococcal choline-binding protein A; PhtD, pneumococcal histidine triad D; PrtA, serine proteinase precursor A. Clinical Microbiology and Infection 2012 18, 756-762DOI: (10.1111/j.1469-0691.2011.03629.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Proportion of seroresponders among bacteraemic children by age category. The proportion of bacteraemic children with a ≥2-fold increase in anti-PSP antibody concentration is illustrated for each pneumococcal surface protein and age group. PcpA, pneumococcal choline-binding protein A; PhtD, pneumococcal histidine triad D; PrtA, serine proteinase precursor A. Clinical Microbiology and Infection 2012 18, 756-762DOI: (10.1111/j.1469-0691.2011.03629.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions