HSPCs Get Their Motors Running for Asymmetric Fate Choice

Slides:

Advertisements

Similar presentations

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Advertisements

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

Stress Can Be a Good Thing for Blood Formation

Stem Cell Maintenance of the Mammary Gland: It Takes Two

Hardwiring Stem Cell Communication through Tissue Structure

Hematopoietic Stem Cells Burn Fat to Prevent Exhaustion

Martin Wahlestedt, David Bryder Cell Stem Cell

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

9-1-1: HSCs Respond to Emergency Calls

Volume 1, Issue 1, Pages (June 2007)

MicroRNA-124: Micromanager of Neurogenesis

Laetitia Seguin, Sara M. Weis, David A. Cheresh Cell Stem Cell

Cell Cycle Rules Pluripotency

The LUNGe to Model Alveolar Lung Diseases in a Dish

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Improving Stem Cell Therapeutics with Mechanobiology

Surveillance for Secure Differentiation

Volume 9, Issue 2, Pages (August 2011)

Volume 16, Issue 6, Pages (June 2015)

Christopher Hine, James R. Mitchell Cell Stem Cell

Metabolic Makeover for HSCs

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Vitamin C: C-ing a New Way to Fight Leukemia

Christopher Hine, James R. Mitchell Cell Stem Cell

Natalia J. Martinez, Richard I. Gregory Cell Stem Cell

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Regulating Cancer Stem Cells the miR Way

Wing Y. Chang, William L. Stanford Cell Stem Cell

Volume 11, Issue 3, Pages (September 2012)

A New Image of the Hematopoietic Stem Cell Vascular Niche

A New Notch for Lung Stem Cells

Stem Cell Therapies in Clinical Trials: Progress and Challenges

On the Origin of the Term “Stem Cell”

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

TRRAP and the Maintenance of Stemness in Gliomas

MicroRNA Regulation of Stem Cell Fate

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Kinetics and symmetry of divisions of hematopoietic stem cells

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Cycling toward Elimination of Leukemic Stem Cells

Mohammad Abdul-Ghani, Lynn A. Megeney Cell Stem Cell

Meddling with METTLs in Normal and Leukemia Stem Cells

Powering Reprogramming with Vitamin C

Copyright © 2013 Elsevier Inc. All rights reserved.

Volume 6, Issue 3, Pages (March 2010)

Hematopoietic Stem Cells in Transit— Where's the Niche?

Vitamin C: C-ing a New Way to Fight Leukemia

Stem Cells and Osteoporosis Therapy

Madeline Niederkorn, Daniel T. Starczynowski Cell Stem Cell

HSC Fate Is Tethered to Mitochondria

Maintaining Hematopoietic Stem Cells in the Vascular Niche

ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity

Volume 22, Issue 1, Pages 5-7 (January 2018)

Using Notches to Track Mammary Epithelial Cell Homeostasis

Cell Migration: Cooperation between Myosin II Isoforms in Durotaxis

Mesp1 at the Heart of Mesoderm Lineage Specification

Ye-Guang Chen, Zhongwei Li, Xiao-Fan Wang Cell Stem Cell

Ya-Huei Kuo, Ravi Bhatia Cell Stem Cell

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

Mark C. Horowitz, Steven M. Tommasini Cell Stem Cell

Presentation transcript:

HSPCs Get Their Motors Running for Asymmetric Fate Choice Yi Zheng, Hartmut Geiger Cell Stem Cell Volume 14, Issue 1, Pages 1-2 (January 2014) DOI: 10.1016/j.stem.2013.12.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Myosin-II Isoforms Regulate HSPC Self-Renewal and Differentiation in Response to Bone Marrow Matrix Mechanics and Cytokines As contractile motors in cell division, MIIA and MIIB serve as sensors of matrix stiffness to affect cell polarity and asymmetric division. MIIA is activated by endosteum-like stiff matrix during HSPC differentiation by dephosphorylation at residue S1943 and maintains p53-dependent cell survival while the differentially expressed and polarized MIIB is required for HSPC asymmetric division and self-renewal. Transient inhibition of both myosin isoforms in culture depletes progenitors and enriches for stem cells. Cell Stem Cell 2014 14, 1-2DOI: (10.1016/j.stem.2013.12.002) Copyright © 2014 Elsevier Inc. Terms and Conditions