Volume 80, Issue 1, Pages (July 2011)

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Volume 80, Issue 1, Pages 93-104 (July 2011) Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts Ron T. Gansevoort, Kunihiro Matsushita, Marije van der Velde, Brad C. Astor, Mark Woodward, Andrew S. Levey, Paul E. de Jong, Josef Coresh Kidney International Volume 80, Issue 1, Pages 93-104 (July 2011) DOI: 10.1038/ki.2010.531 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Pooled hazard ratios (95% confidence interval) for ESRD according to spline eGFR (upper panels) and albumin-to-creatinine ratio (lower panels), adjusted for each other and for age, sex, and cardiovascular risk factors (continuous analyses). Reference categories are eGFR 95ml/min per 1.73m2 and albumin-to-creatinine ratio 5mg/g or dipstick negative or trace. Left panels show results for general population cohorts, and right panels for high-risk cohorts. Dots represent statistical significance, triangles represent non-significance, and shaded areas are 95% confidence interval. ACR, albumin-to-creatinine ratio; AKI, acute kidney injury; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; GP cohorts, general population cohorts; HR, hazard ratio; HR cohorts, high-risk cohorts. Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 Pooled adjusted hazard ratios or odds ratios (95% confidence interval) for ESRD (upper panels), acute kidney injury (middle panels), and progressive chronic kidney disease (lower panels) according to eGFR and albuminuria based on continuous models with eGFR (splines), albuminuria (log-linear albumin-to-creatinine ratio or categorical dipstick), and their interaction terms. Hazard ratios are adjusted for age, sex, and cardiovascular risk factors. Reference category is eGFR 95ml/min per 1.73m2 plus albumin-to-creatinine ratio 5mg/g or dipstick negative or trace. Left panels shows results for general population cohorts, and right panels for high-risk cohorts. Dots represent statistical significance, triangles represent non-significance, and shaded areas are 95% confidence interval. In this figure, albuminuria is treated categorically. Black lines and blue shading represent an albumin-to-creatinine ratio <30mg/g or dipstick negative or trace, green lines and green shading an albumin-to-creatinine ratio 30–299mg/g or dipstick 1+, and red lines and red shading an albumin-to-creatinine ratio ≥300mg/g or dipstick ≥2+. AKI, acute kidney injury; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; GP cohorts, general population cohorts; HR, hazard ratio; HR cohorts, high-risk cohorts; OR, odds ratio; pCKD, progressive chronic kidney disease. Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions

Kidney International 2011 80, 93-104DOI: (10.1038/ki.2010.531) Copyright © 2011 International Society of Nephrology Terms and Conditions