Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin.

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Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin. Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin. (A) Five to seven male mice in each group were inoculated s.c. with 1.0 × 106 TCID50 of SFTSV (SPL010). Mice were treated with ribavirin at a dose of 25 or 100 mg/kg/day or T-705 at a dose of 60 or 300 mg/kg/day. The drugs were administered intraperitoneally once daily. Placebo mice received the same volume of PBS. Treatment was continued for 5 days as indicated in the upper columns (shaded in gray with the survival curves). Survival was determined using Kaplan-Meier analysis and GraphPad Prism6. Relative weight is shown as means with standard deviations. (B) SFTSV RNA levels in blood samples collected at 2, 4, 7, or 11 days postinfection were determined by quantitative RT-PCR assays. One-way ANOVA with Bonferroni’s multiple-comparison test was used to determine the level of statistical significance. Dashed lines indicate the detection limits of the assay in blood samples. Significance was determined in comparison to the results of the placebo group: **, P < 0.01; *, P < 0.05; N.T., not tested. Hideki Tani et al. mSphere 2016; doi:10.1128/mSphere.00061-15