Coxibs—Beyond the GI Tract

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Presentation transcript:

Coxibs—Beyond the GI Tract Anthony N. DeMaria, MD, Matthew R. Weir, MD Journal of Pain and Symptom Management Volume 25, Issue 2, Pages 41-49 (February 2003) DOI: 10.1016/S0885-3924(02)00630-9

Fig. 1 Distribution of COX-1 and COX-2 in the human kidney. Journal of Pain and Symptom Management 2003 25, 41-49DOI: (10.1016/S0885-3924(02)00630-9)

Fig. 2 Role of prostaglandins in the kidney. Journal of Pain and Symptom Management 2003 25, 41-49DOI: (10.1016/S0885-3924(02)00630-9)

Fig. 3 Vascular events with rofecoxib: meta-analysis of studies of (6 months' duration or more).41 Relative risk (95% CI) of the APTC (Antiplatelet Trialist Collaboration) end point for rofecoxib relative to placebo, non-naproxen NSAIDs, and naproxen in studies ≥6 months in duration. Triangles represent relative risk, and size of triangles represents patient-years of exposure. Journal of Pain and Symptom Management 2003 25, 41-49DOI: (10.1016/S0885-3924(02)00630-9)