Volume 41, Issue 5, Pages (June 2017)

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Volume 41, Issue 5, Pages 453-454 (June 2017) At the Crossroads between Cell Polarity and Adhesion in Neocortical Development Sergei Y. Sokol Developmental Cell Volume 41, Issue 5, Pages 453-454 (June 2017) DOI: 10.1016/j.devcel.2017.05.017 Copyright © 2017 Terms and Conditions

Figure 1 N-Cadherin Is Stabilized at Apical Cell Junctions by Lgl1 and aPKC Protein interactions in the apical-lateral corner of a V/SVZ neuroepithelial progenitor are shown. The binding of N-cadherin by Lgl1 along the basolateral surface of the radial glial progenitor results in N-cadherin internalization (red arrow); however, aPKC antagonizes this interaction by phosphorylating Lgl1 at cell junctions, leading to selective junctional accumulation of N-cadherin in normal embryos. In Lgl1 mutant tissues, N-cadherin accumulates throughout the basolateral surface, causing disorganization of the AJC. Developmental Cell 2017 41, 453-454DOI: (10.1016/j.devcel.2017.05.017) Copyright © 2017 Terms and Conditions