Spermatogonial survival in long-term human prepubertal xenografts

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Spermatogonial survival in long-term human prepubertal xenografts Ellen Goossens, Ph.D., Mieke Geens, M.Sc., Gert De Block, Herman Tournaye, M.D., Ph.D.  Fertility and Sterility  Volume 90, Issue 5, Pages 2019-2022 (November 2008) DOI: 10.1016/j.fertnstert.2007.09.044 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Human prepubertal testicular tissue grafted on the backs of immunodeficient mice. (A, C, E) MAGE-A4–positive cells: spermatogonia. (B, D, F) Vimentin-positive cells: Sertoli cells. (A, B) Immature human testis tissue before grafting. The tubules contain Sertoli cells and spermatogonia. (C, D) Testicular tissue 4 months after grafting. (E, F) Testicular tissue 9 months after grafting. Spermatogonia remain in some seminiferous tubules. Bar = 70 μm. Fertility and Sterility 2008 90, 2019-2022DOI: (10.1016/j.fertnstert.2007.09.044) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

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