Zeynep Eroglu, MD, Jae Kim, MD, Sharon Wilczynski, MD, PhD, Warren A

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Presentation transcript:

Complete Pathologic Response in Soft Tissue Sarcoma Lung Metastases with Pazopanib Zeynep Eroglu, MD, Jae Kim, MD, Sharon Wilczynski, MD, PhD, Warren A. Chow, MD Journal of Thoracic Oncology Volume 9, Issue 1, Pages e4-e6 (January 2014) DOI: 10.1097/JTO.0b013e3182a4700d Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Restaging CT scan after doxorubicin and ifosfamide chemotherapy on July 5, 2012 (left) demonstrated progression in the two left-sided pulmonary nodules, up to 18 mm. Patient was treated with pazopanib. Follow-up CT scan on September 27, 2012 (right) demonstrated a marked regression in the left-sided pulmonary metastases from 18 to 8 mm. CT, computed tomography. Journal of Thoracic Oncology 2014 9, e4-e6DOI: (10.1097/JTO.0b013e3182a4700d) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Response in the largest right-sided pulmonary lesion from 5 to 2 mm after 2 months of pazopanib. Arrows indicate the lung metastases responding to pazopanib. Journal of Thoracic Oncology 2014 9, e4-e6DOI: (10.1097/JTO.0b013e3182a4700d) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 A, Pulmonary metastasis biopsy (May 17, 2012): the high power (H&E, 40×) demonstrates a high-grade spindle cell sarcoma with highly pleomorphic cells, bizarre multinucleated giant cells, and numerous mitotic figures. B, Wedge resection of pulmonary metastases (October 22, 2012) that had regressed on CT imaging after pazopanib was initiated showed only fibrosis, mild inflammatory infiltrate of histiocytes, and a few lymphoid cells. No viable tumor was identified (H&E, 4×). CT, computed tomography; H&E, hematoxylin and eosin. Journal of Thoracic Oncology 2014 9, e4-e6DOI: (10.1097/JTO.0b013e3182a4700d) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions