Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

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Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients. TLR8 is aberrantly expressed on pDCs from SSc patients. (A) TLR8 expression levels [relative Ct (Rel Ct)] were quantified in purified pDCs [n = 18 HDs; n = 29 SSc patients; n = 6 systemic lupus erythematosus (SLE) patients], B cells (n = 14 HDs; n = 8 SSc patients), or monocytes (n = 17 HDs; n = 11 SSc patients) from PBMCs as indicated. (B to D) Gene expression level of TLR7, TLR9, and TLR10 was quantified in (B) purified pDCs (n = 17 to 18 HDs; n = 29 to 31 SSc patients; n = 6 SLE patients), (C) purified B cells (n = 12 to 14 HDs; n = 6 to 8 SSc patients), or (D) purified monocytes (n = 16 to 18 HDs; n = 11 SSc patients) by quantitative polymerase chain reaction (qPCR). All results are represented as means ± SEM. Statistical significance was evaluated using a Mann-Whitney U test, and only comparisons that are significant are shown. *P < 0.05, **P < 0.01, ***P < 0.001. Marie Dominique Ah Kioon et al., Sci Transl Med 2018;10:eaam8458 Published by AAAS