Low Frequency of Lynch Syndrome Among Young Patients With Non-Familial Colorectal Cancer  Ajay Goel, Takeshi Nagasaka, Jennifer Spiegel, Richard Meyer, Warren E. Lichliter, C. Richard Boland  Clinical Gastroenterology and Hepatology  Volume 8, Issue 11, Pages 966-971.e1 (November 2010) DOI: 10.1016/j.cgh.2010.06.030 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Relationship between location of tumor in the colon and various diagnostic features including DNA MMR-IHC status, MSI, KRAS and BRAF mutations. Blue bars represent frequency of tumors occurring in the distal colon, and orange bars are indicative of the proximal location. As shown, a majority of younger non-familial CRCs occur in the distal colon, and their location is independent of MMR status. Clinical Gastroenterology and Hepatology 2010 8, 966-971.e1DOI: (10.1016/j.cgh.2010.06.030) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 ROC illustrating sensitivity and specificity of pentaplex MSI assay used for detection of DNA MMR deficiency in our cohort of CRCs. There is a significantly high degree of correlation between mutations at microsatellite markers and corresponding loss in expression of MMR protein in younger non-familial CRCs. Clinical Gastroenterology and Hepatology 2010 8, 966-971.e1DOI: (10.1016/j.cgh.2010.06.030) Copyright © 2010 AGA Institute Terms and Conditions